Agnieszka Nikiforuk Selected Research

Schizophrenia (Dementia Praecox)

10/2023	Pro-social and pro-cognitive effects of LIT-001, a novel oxytocin receptor agonist in a neurodevelopmental model of schizophrenia.
1/2021	Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT3 and 5-HT6 Receptor Antagonist with Antipsychotic and Procognitive Properties.
1/2021	Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats.
1/2020	Social dysfunction in the neurodevelopmental model of schizophrenia in male and female rats: Behavioural and biochemical studies.
12/2018	Procognitive effects of varenicline in the animal model of schizophrenia depend on α4β2- and α 7-nicotinic acetylcholine receptors.
8/2018	Assessment of cognitive functions in animal models of schizophrenia.
2/2018	Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
1/2018	Kynurenine pathway in schizophrenia: Galantamine-memantine combination for cognitive impairments.
1/2018	Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in a ketamine-based animal model of schizophrenia.
1/2017	3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats.

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Agnieszka Nikiforuk Research Topics

Disease

25	Schizophrenia (Dementia Praecox) 10/2023 - 01/2010
21	Cognitive Dysfunction 01/2021 - 12/2010
5	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2014
2	Inflammation (Inflammations) 10/2021 - 08/2004
2	Mental Disorders (Mental Disorder) 08/2012 - 01/2012
2	Shock 09/2007 - 12/2006
2	Carcinogenesis 08/2004 - 07/2003
1	Autistic Disorder (Autism) 11/2022
1	AIDS-Related Complex (ARC) 01/2021
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2021
1	Treatment-Resistant Depressive Disorder 10/2020
1	Memory Disorders (Memory Loss) 01/2020
1	Amnesia (Dissociative Amnesia) 03/2015
1	Central Nervous System Diseases (CNS Diseases) 05/2013
1	Pain (Aches) 06/2007
1	Hyperalgesia 06/2007
1	Visceral Pain 06/2007
1	Chronic Pain 06/2007
1	Neuralgia (Stump Neuralgia) 06/2007
1	Seizures (Absence Seizure) 07/2006

Drug/Important Bio-Agent (IBA)

12	Ketamine FDA LinkGeneric 10/2020 - 01/2010
11	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2020 - 04/2011
5	LigandsIBA 11/2022 - 08/2004
5	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 01/2021 - 08/2015
4	Memantine (Namenda)FDA Link 01/2020 - 10/2016
3	Glutamic Acid (Glutamate)FDA Link 10/2021 - 04/2011
3	serotonin 6 receptorIBA 01/2021 - 05/2013
3	Galantamine (Galanthamine)FDA LinkGeneric 01/2020 - 01/2018
3	Antipsychotic Agents (Antipsychotics)IBA 01/2017 - 01/2016
3	Serotonin (5 Hydroxytryptamine)IBA 01/2016 - 05/2013
3	serotonin 7 receptorIBA 07/2013 - 01/2012
3	Antidepressive Agents (Antidepressants)IBA 01/2011 - 12/2006
2	Methylazoxymethanol AcetateIBA 10/2023 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2004
2	1- (5- chloro- 2,4- dimethoxyphenyl)- 3- (5- methylisoxazol- 3- yl)ureaIBA 01/2021 - 01/2020
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2020 - 10/2016
2	Scopolamine (Hyoscine)FDA Link 01/2020 - 10/2019
2	Donepezil (Aricept)FDA LinkGeneric 01/2020 - 01/2018
2	Cholinergic Agents (Cholinergics)IBA 01/2018 - 01/2016
2	Biomarkers (Surrogate Marker)IBA 01/2018 - 07/2003
2	N-Methylaspartate (NMDA)IBA 01/2018 - 01/2010
2	Quetiapine Fumarate (Seroquel)FDA Link 01/2013 - 03/2012
2	SB 269970IBA 01/2013 - 12/2006
2	Anti-Anxiety Agents (Anxiolytics)IBA 09/2007 - 12/2006
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2004 - 07/2003
2	PPAR gammaIBA 08/2004 - 07/2003
2	GastrinsIBA 08/2004 - 07/2003
1	Oxytocin (Pitocin)FDA LinkGeneric 10/2023
1	LIT-001IBA 10/2023
1	Oxytocin Receptors (Oxytocin Receptor)IBA 10/2023
1	Ondansetron (Zofran)FDA LinkGeneric 01/2021
1	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 01/2021
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	EsketamineIBA 10/2020
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2020
1	NeurotoxinsIBA 01/2020
1	naphthaleneIBA 10/2019
1	AminesIBA 10/2019
1	PNU-282987IBA 12/2018
1	metanicotineIBA 12/2018
1	Varenicline (Chantix)FDA Link 12/2018
1	Cholinergic ReceptorsIBA 12/2018
1	Therapeutic UsesIBA 02/2018
1	Dopamine D2 Receptors (Dopamine D2 Receptor)IBA 02/2018
1	KynurenineIBA 01/2018
1	Metabotropic Glutamate 5 ReceptorIBA 01/2018
1	Kynurenic Acid (Kynurenate)IBA 01/2018
1	alpha7 Nicotinic Acetylcholine ReceptorIBA 01/2017
1	positive allosteric modulator PAM-2IBA 01/2017
1	3-(2,4-dimethoxybenzylidene)anabaseineIBA 01/2017
1	Acetylcholine (Acetylcholine Chloride)FDA Link 01/2017
1	Dopamine D1 Receptors (Dopamine D1 Receptor)IBA 01/2016
1	Nootropic Agents (Nootropics)IBA 01/2016
1	serotonin 5 receptorIBA 01/2016
1	SCH 23390IBA 01/2016
1	Excitatory Amino Acid AntagonistsIBA 12/2015
1	Clozapine (Clozaril)FDA LinkGeneric 03/2015
1	Amisulpride (Solian)IBA 01/2013
1	SK&F 81297IBA 08/2012
1	Metyrapone FDA Link 01/2011
1	SteroidsIBA 01/2011
1	CorticosteroneIBA 01/2011
1	N- (4- (2- methoxyphenoxy)phenyl)- N- (2,2,2- trifluoroethylsulfonyl)pyrid- 3- ylmethylamineIBA 12/2010
1	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 12/2010
1	metabotropic glutamate receptor 2IBA 12/2010
1	Mazindol (Mazanor)FDA Link 01/2010
1	Glutamate Receptors (Glutamate Receptor)IBA 01/2010
1	Anesthetics (Anesthetic Agents)IBA 01/2010
1	SB 258585IBA 09/2007
1	quinone (benzoquinone)IBA 06/2007
1	KaolinIBA 06/2007
1	Freund's AdjuvantIBA 06/2007
1	Streptozocin (Streptozotocin)FDA Link 06/2007
1	Sulpiride (neogama)IBA 06/2007
1	Phenyl-P adhesion promoting monomerIBA 06/2007
1	bicifadineIBA 06/2007
1	Anticonvulsants (Antiepileptic Drugs)IBA 07/2006

Therapy/Procedure

4	Therapeutics 06/2020 - 05/2013
1	Ligation 06/2007